Organic Chemistry

Biography

Elena R Milaeva pursued PhD at the A N Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences in 1980. She is currently a Professor of organic chemistry, head of the department of medicinal chemistry & fine organic synthesis at Lomonosov Moscow State University respectively. Her research interests include: organic chemistry, medicinal chemistry, organometallic chemistry.

Abstract

The presentation will focus on a novel approach to construction of physiologically active organic and organometallic compounds based on computer-aided design, new synthetic approaches and extensive biological screenings. This study is focused on the design of hybrid compounds possessing 2,6-dialkylphenol group with dual modes of action– prooxidative activity and antioxidative activity. The presence of metal atom allows extensive modification including coordination to the targeted specific groups to control and tune toxicity-activity profiles. The synthesis and biological activity will be discussed. The anti/prooxidant activity has been studied in vitro, ex vivo, in vivo experiments.